Burn More Total Calories and More Calories from Fat Than Diet and Exercise Alone.

The New Science of Multi-Functional Hybrid Formula Design

MethylBURN’s advanced multi-functional hybrid formula design is based on revolutionary pharmaceutical multi-target drug hybrid technology. Pharmaceutical hybrid technology is aimed at creating compounds capable of interacting with more than one metabolic target simultaneously to achieve great desired effects. When MuscleMeds’ researchers conducted their investigation into the most recent advancements in the science of thermogenesis and the physiological variables that influence both the storage and utilization of adipose tissue (body fat), they uncovered many new discoveries. The MuscleMeds research team then took on the task of solving this metabolic puzzle and embarked on a project that they called “Fat Map.” Project “Fat Map,” the mapping out of the multiple metabolic pathways which influence body fat, led to the development of the MuscleMeds Thermogenic Fat-Burning Cascade model. This model identifies the key physiologic targets that need to be acted upon in order to accomplish a significant rise in calorie burning and use of fats for energy production.

Based on this new Thermogenic Fat-Burning Cascade model, MuscleMeds research realized that in order to optimize fat burning and address these multiple pathways it would require the development an advanced hybrid formulation. Upon performing their scientific evaluation, it was apparent that developing a conventional product like those that currently existed would not be optimally effective. This new model also explains why people may feel a temporary buzz and minor energy boost typical of generic thermogenic products, but are not experiencing the desired fat loss boosting effects when using weight loss products.

The MuscleMeds research team determined that there was a need to create a new type of thermogenic product, one that would incorporate the new multi-target hybrid design to not only increase thermogenesis (calorie burning), but would have vital multiple actions on the entire Thermogenic Fat-Burning Cascade. This new thermogenic product would also increase the fat-burning rate and sustain the following effects:

• Lipolysis activation
• Thermogenic stimulation
• Thermogenic sustainment and increased metabolic rate
• Sustainment
• Enhance exercise performance, energy and appetite control

MuscleMeds researchers successfully achieved this monumental task and thus, the world’s first Thermodynamic Fat-Burning Hybrid was born – MethylBURN Extreme!

Burn More Total Calories, Burn More Calories From Fat Tissue, Prevent Loss of Muscle Tissue.

MethylBURN Ingredients and Actions Overview

• Rapidly and completely absorbed
• Peak plasma concentrations
• Longer half-life (up to several hours of bioactivity)
• Direct and synergistic thermogenic and fat metabolizing effects

Methylation

In nature, biochemicals exist in various forms, which scientists have determined display different rates of intestinal absorption and bioactivity in the body based on characteristics of their molecular design. From researching the pharmacokinetics of thousands of biochemicals, it was determined that for certain compounds, their methlyated compound versions are better absorbed and therefore have increased bioavailability, making them more bioactive in the body. Therefore, methylation is a sort of “capping” of a molecule’s reactive biochemical structure. When these reactive groups are methylated, this prevents other reactive substances from combining with them, which increases their rate of absorption. Once in the body, the methylation also protects the molecules from metabolic destruction, in particular from the liver. Once these methlyated bioactive molecules are circulated to the body’s tissues, they can go to work to perform their intended functions.

This differential bioavailability phenomenon led MuscleMeds researchers down the road of ingredient discovery, a journey that resulted in the inclusion of methylated versions of the key ingredients that resulted in improved bioactivity.

FastBurn™ Methylated Thermogenic Matrix: Methyl-Synephrine (Beta-Receptor Agonist)

Methyl-Synephrine is a naturally occurring compound that research has reported can stimulate thermogensis. The Methylated Synephrine used in MethylBURN provides for increasing the stability and bioavailability of this ingredient, getting more into the body at a faster rate. Methylation provides an additional benefit from increasing the half-life once in the bloodstream, which extends its duration of action and effectiveness. Methyl-Synephrine stimulates the Thermogenic Fat-Burning cascade through two primary modes of action: 1) Exerts direct beta-receptor stimulatory action, in particular higher stimulation of the Beta-3 receptors reported to be of vital importance for maximizing the thermogenic fat-burning effect and 2) Stimulates the increase of the body’s naturally occurring thermogenic activating substances, namely, norepinephrine (noradrenaline) and adrenaline (epinephrine).

Methyl-Beta Phenethylamine (Neurotropic Regulator and Synergist)

Methyl-Beta Phenethylamine (Methyl-Beta PEA) is a psychotropic monoamine. In the human brain, it is reported to function as a neuromodulator or neurotransmitter and elicits extreme psychoactive effects on the body while triggering body fat metabolism. Methyl-Beta PEA enters the brain and triggers a cascading release of dopamine and stimulates the mesolimbic reward pathway, causing desirable mood-elevating action, promoting euphoria, excitement and satisfaction. Methyl-Beta PEA provides additional thermogenic synergistic action through potentiating norepinephrine production. This special Methyl-Beta PEA molecular configuration increases the half-life in the body and prolongs the psychotropic and synergistic thermogenic enhancing actions. Methyl-Beta PEA is also shown to exhibit powerful appetite suppression actions.

Methyl-Tryamine (Beta-Receptor Agonist)

Methyl-Tryamine serves multiple functions in the formula to enhance the thermogenic effect. Methyl-Tryamine is a monoamine compound, which is reported to cause the release of other monoamines/catecholamines, such as dopamine, norepinephrine and epinephrine. Methyl-Tryamine also has MAO inhibiting activity. In the MethylBURN formulation, Methyl-Tryamine acts directly and synergistically to enhance the beta-receptor stimulated thermogenesis to optimize the fat metabolizing effects. As a MAO inhibitor, this helps to reduce the MAO enzyme’s breakdown of Methyl-Beta Phenylethylamine (Methyl-Beta PEA), thereby enhancing its beneficial effects.

Caffeine (Lipolytic Action Enhancer, Thermogenic Catalyst, Phosphodiesterase Inhibitor, Adenosine Receptor Blocker, Methyl-Beta PEA Enhancer)

Pharmaceutical quality caffeine plays a few roles in increasing fat metabolism and thermogenesis in addition to its ability to increase mental and physical performance. It is both a central nervous system and metabolic stimulant. Caffeine administration has been reported to help increase lipolysis and to promote a shift in the energy utilization of body fat. As an inhibitor of phosphodieserases, caffeine increases cAMP levels which help it function as a metabolic-supercharger. This greatly enhances and intensifies the thermogenic effects of norepinephrine and epinephrine. Furthermore, caffeine also contributes to increasing the lipolysis process, which mobilizes fats from stored body fat into the bloodstream to be used as a source of energy by muscles and other body tissues, thereby enhancing the availability of fatty acids to be used for energy production.

Additionally, caffeine exerts effects as an antagonist of adenosine receptors. Adenosine is found in every part of the body, playing a vital role in ATP related energy metabolism and additional special functions in the brain. Some evidence indicates that the adenosine receptor system interacts with the dopamine system, which is involved in mood enhancement, pleasure and arousal. The reduction in adenosine from caffeine blocking the adenosine receptor site leads to increased activity of dopamine, enhancing the effects of Methyl-Beta PEA.

These potent properties of MethylBURN’s pharmaceutical quality caffeine are an important adjunct to the overall formula of MethylBURN to enhance fat loss and increase exercise performance.

Niacin & Vitamin B12 (Synergists)

Niacin plays an essential role in energy production and was shown in a research study to boost the calorie burning rate when used in combination with other MethylBURN ingredients. Vitamin B12 plays multiple roles in the body, including essential functioning as an enzyme needed to speed up the metabolism of fats and other energy substrates.

AfterBurn™ Thermogenic Sustaining Agents 4-(4-Hydroxphenyl)butan-2-one (RK) (Norepinephrine LIpolytic Agent)

RK is a recently discovered new fat-burning compound with compelling data gathered from research conducted on RK’s thermogenic effects in animal studies. These impressive studies have led scientists to explore the potential thermogenic effects on humans. The structure of RK is similar to the structures of other thermogenic stimulating substances like capsaicin and synephrine. RK significantly increased norepinephrine induced lipolysis associated with the translocation of hormone sensitive lipase from the cytosol to lipid droplets in experimental fat cells. The researchers reported that the lipid metabolism effects of 4-(4-Hydroxphenyl)butan-2-one (RK) appear to stem from the action in altering the lipid metabolism or, more specifically, in increasing norepinephrine induced lipolysis in white adipocytes.

Capsimax™ Capsaicin Fruit Extract (Metabolic Optimizer)

Capsimax (a proprietary form of capsaicin) and purified capsaicin have been subject to research studies reporting on the thermogenic enhancing benefits and role as fat loss aids. As part of a thermogenic blend containing niacin, caffeine and capsimax, an impressive preliminary research study reported a significant increase in energy production after a workout as compared to people taking a placebo. Subjects taking the exact caspimax, caffeine and niacin blend contained in MethylBURN prior to exercise experienced increased metabolism before, during and after exercise. The subjects burned up to 278 more extra calories cumulatively when compared to the placebo group. The majority of extra calorie burning was reported to occur after exercise, which is why Capsimax is a featured ingredient in the AfterBurn blend. Subjects actually burned more than 12 times more calories one hour after exercise. The researchers also reported improved exercise performance, an extra benefit for people who are serious about improving their exercise effectiveness.

Oxcenerate™ (3,3′-dihydroxy-β-carotene-4,4′-dione) (Lipid Metabolizer)

In independent research studies, Oxcenerate was reported to produce important physical benefits as determined from clinical trials and laboratory supporting studies. Oxcenerate was shown to promote increased endurance, reduced muscle damage and improved lipid metabolism. Increased lipid metabolism allows for the utilization of fat rather than carbohydrate as the main source of energy during strenuous activity. This adds to the overall MethylBURN Thermogenic Fat-Metabolizing effect of using more fat for energy, while helping to spare muscle glycogen.

The mechanism behind muscle endurance is based on several findings. Generally, Ocenerate protected the skeletal muscle from the increased damage of oxidative stress generated by physical activity. Furthermore, Oxcenerate was shown in a research study to increase the metabolism of lipids as the main source of energy production by protecting the carnitine palmitoyltransferase I (CPT I), a key enzyme involved in fatty acid transport into mitochondria. Yet another study with humans found that Ocenerate increased exercise performance, in particular increasing reps. Based on the findings of the research studies, Ocenerate has the ability to help increase fat metabolism and improve strength endurance that may lead to sports performance as well as weight loss.

Yohimbine HCl (Alpha 2 Agonist, Methyl-Beta PEA Enhancer)

Yohimbine is an effective alpha 2-adrenoreceptor blocker, effective for increasing serum levels of norepinephrine. Yohimbine therefore promotes fat oxidation by increasing norepinephrine levels, in addition to desirable alpha-receptor antagonism (blocking) to help to maximize and sustain MethylBURN’s powerful thermogenic fat-burning effects. When the body’s thermogenic catecholamine production is increased via the direct acting beta-receptor activating MethylBURN ingredients and from the additional production of norepinephrine and adrenaline, simulation of the alpha-2 receptor occurs. This alpha-2 receptor stimulation results in down regulating the thermogenic effects. So, in addition to prolonging the fat-burning beta receptor stimulating effects by the special methylated MethylBURN ingredients, yohimbine produces additional thermogenic benefits from blocking Alpha-2 receptor activation. Yohimbine, as an Alpha-2 receptor antagonist, essentially neutralizes this negative feedback signaling and prolongs the thermogenic stimulating effects for longer periods of time. This helps to keep the fat-burning thermogenic effect going to burn more total calories and maximize the overall fat loss aid actions of the MethylBURN Beta-receptor stimulating effects.

Bioperine® Black Pepper Extract (Bioavailability enhancer)

Bioperine is a patented ingredient designed to increase the bioavailability of nutritional compounds, i.e. a bioavailability enhancer. Bioperine significantly enhances the bioavailability of supplement nutrients tested through increased intestinal absorption. Bioperine is a special standardized extract from the fruit of Piper nigrum (black pepper) or Piper longum (long pepper), and contains 95 percent of piperine. Potential mechanisms for increased nutrient bioavailability via promoting rapid absorption of nutrients include:

• INCREASED BLOOD SUPPLY TO THE GI TRACT
• INCREASED EMULSIFYING CONTENT OF THE GUT
• INCREASED ACTIVE NUTRIENT TRANSPORT

Bioperine is also referred to as Thermonutrient, as the piperine has been reported in scientific studies to stimulate thermogenesis. Bioperine therefore helps to potentiate MethylBURN’s fast-acting absorption and powerful thermogenic enhancing effects.
MethylBurn Extreme- Clinically Tested, Scientifically Substantiated to Deliver Results

By now, you undoubtedly realize why other weight loss products you’ve used in the past haven’t been effective in helping you achieve successful fat loss. Just as you must perform multiple curling exercises to build massive biceps, it’s critical to employ multiple physiological pathways to maximize fat loss. As a result of MuscleMeds cutting edge research, MethylBURN Extreme is the key to unlock unsurpassed fat-burning potential and create a lean, ultra-ripped physique.

MethylBURN’s powerful fat-burning action is a result of MuscleMeds’ advanced research effort to elucidate the underlying mechanisms of optimizing the Thermogenic Fat-Burning Cascade. MethylBURN Extreme is designed to strategically target the reduction of body fat while preserving muscle mass. Based on a plethora of the most recent scientific discoveries as to the vital bio-chemical mechanisms of action underlying fat metabolism, MethylBURN’s hybrid design targets multiple physiological pathways of fat-burning metabolism, utilizing potent, synergistic ingredients contained in its two proprietary compounds – FastBurn Methylated Thermogenic Matrix and AfterBurn Thermogenic Sustaining Agent. MethylBURN Extreme’s pharmaceutical hybrid design sets a new standard in fat burning supplementation with clinically tested, scientifically substantiated ingredients delivering real results.